Schistosomiasis-from immunopathology to vaccines.

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Schistosomiasis bilharzia is a neglected tropical ailment caused by trematode worms of the genus Schistosoma. The transmission cycle involves human or other mammalian water acquaintance with surface water contaminated by faeces or urine, as well as aspect freshwater snails acting as intermediate hosts. The main disease-causing species are S. According to the World Health Organisation, over million people are infected all-inclusive, leading to considerable morbidity and the estimated loss of 1. Schistosomiasis is characterised by focal epidemiology and an over-dispersed population distribution, with higher bug rates in children. Complex immune mechanisms lead to the slow acquisition of immune resistance, but innate factors additionally play a part.

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